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Methyl-Plex B by NuMedica is a comprehensive formula designed to support healthy homocysteine levels and optimal methylation.* The 5-MTHF in this formula, QuatrefolicÂ®, is the most biologically active form of folate, allowing rapid uptake into the bloodstream.* The 5-MTHF in this formula is also known as the "L" form of 5-MTHF since it is the reduced form of folate. B vitamins are provided in their active forms to support enhanced methylation and cardiovascular health.*