Enzymes: Protease 375K
Advanced Enzyme Formula

Price: $28.00
Quantity: 60 capsules

Ingredients: TzymeTM Protease Blend (360,000 HUT), acid, neutral, alkaline, exo/endo peptidases, bromelain and papain (600,000 PU) and Calcium citrate (9.60 mg)

Description**
TPPTM Protease is a proprietary blend of highly active proteolytic enzymes with a wide range of pH stability. Proteolytic enzymes taken orally under certain conditions have been shown to be absorbed in substantial quantities into the blood.1,2,3 Once in the blood circulation, the enzymes in this blend bind to serum proteins, particularly alpha 2-macroglobulin (a2M), and impart immunomodulatory benefits.4 One of the best-established functions served by the oral proteases in Tzyme blend is in the maintenance of normal blood flow. This is accomplished by breaking down blood clots (fibrinolysis) and platelet aggregation within blood vessels and breaking down excess extra-vascular plasma proteins as in edema. TPPTM Protease will also enhance the hydrolysis of food proteins for enhanced bio-availability of amino acids.

Modulation of the Immune System: As a result of their coupling to 2M, TzymeTM proteolytic enzymes exhibit an increased binding of several very important cytokines (hormones-like molecules which have a powerful influence on immune cells) such as Transforming growth factor-beta (TGP-B), and Tumor Necrosis Factor-alpha (TNF-a).5 Studies have indicated that oral hydrolytic enzymes affect cytokine synthesis and modulatory effects.6 For instance, TNF-a synthesis, which is a necessary step in host defense against tumor cells,7 is impaired when experimentally inactivated oral proteolytic enzymes were used.8

Thus, active, GI stable and functional oral enzymes that are absorbed in the blood stream can provide therapeutic applications. In addition, studies have shown that oral proteolytic enzymes increased the tumoricidal and cytotoxic activities of polymorphonuclear neutrophils.9

Bromelain, an important addition to the TzymeTM Protease Blend, is a protease derived from the pineapple plant. It has been used for many years as a digestive aid, anti-inflammatory and burn debridement agent. Its actions help to prevent swelling/edema, promote smooth muscle relaxation, inhibit platelet aggregation, and enhance antibiotic absorption. Bromelain is also used in cancer treatment, ulcer prevention, sinusitis relief, appetite inhibition and shortening of labor.10,11 Proteolytic enzymes administered orally improved the survival time, the hematological parameters of spontaneous lymphoblastic leukemia in rats, and the metastasis and survival time of mice with Lewis lung carcinoma.12

Several hypotheses have been put forth as to the mechanisms by which proteolytic enzymes modulate the immune system to control and eliminate tumors. Some studies indicated that proteolytic enzymes selectively remove some adhesion molecules such as CD4, CD44, B7-1, ICAM-1, B7-2, CD45RA, CD6, CD7, E2/MIC2, and Leu81/LAM 1 from cell surfaces.13,14,15,16 According to Hale et al.16 the removal of these surface molecules has markedly enhanced CD2 mediated T-cell activity.

Some studies have implied that by removing the glycoprotein CD44, some proteases help control the tumor growth of certain types of cells. This selective removal of some mediator proteins, and the regulation of cytokines19,8,6,5 constitute some factors by which proteolytic enzymes are thought to modulate the immune system and act as biological response modifiers.

Indications:
Impaired Kidney Function - Glomerulonephritis: In this disease there is a build up of protein in the basement membrane of the glomeruli of the kidneys. Fluids must pass through this basement membrane in the initial phase of the filtration of the blood by the kidneys. Recent research using an animal model of this disease "lends further support to the concept that enzymes capable of degrading immune complexes in situ can ameliorate glomerulonephritis".17

Heavy Metal Toxins - Heavy metals such as lead (Pb) and mercury (Hg) exert their poisoning effect by binding to ionizable or sulfhydryl groups of proteins, including vital enzymes. Once these metals bind to an essential functional protein, such as an enzyme, they denature and/or inhibit it. This interaction of heavy metals to proteins can lead to degenerating diseases, nerve damage or even death.

When taken on an empty stomach, it should be noted that protease is readily taken up into the mucosa cells of the intestine and passed into blood circulation. Clinical observations have noted that upon high intake of TPPTM Protease, heavy metal concentrations have been significantly decreased in the blood.

Recommended Dosages:
Take one (1) capsule two times daily on an empty stomach with 8 oz. of water. If you have difficulty swallowing capsules remove contents from capsule, mix with a small amount of tepid water and ingest immediately.

Dosage may be increased according to need and/or as indicated by your health care professional.

References:

** Disclaimer: All information presented by Natural Healing House is for educational purposes only. The articles are not intended to substitute for a consultation with your physician. In case of medical questions or uncertainties, the reader is encouraged to seek the advice of his/her own physician or health care practitioner. The products listed have not been evaluated by the FDA and, therefore, cannot claim to treat, diagnose, cure or prevent any disease.