Enzymes: Inflammatory Control
Advanced Enzyme Formula
Price: $26.25
Quantity: 60 capsules
Price: $48.00
Quantity: 120 capsules
Ingredients: TzymeTM Protease Blend (213,000
HUT), acid, neutral, alkaline, exo/endo peptidases, bromelain
and papain (3,108,000 PU) and Calcium citrate (2.7 mg),
TzymeTM Anti-Ox Blend (Catalase 26 CatU, SOD 51 McCord-Fridovitch,
Glutathione 2.6 mg, Quercetin 21.6 mg, Mg ascorbate 3.1
mg, Ascorbic acid 12.5 mg, Rutin 44 mg, Grape seed extract
22.8 mg, Lycopene 1.25 mg, Lutein 1.56 mg, Hesperdin complex
1.56 mg, Ginko biloba leaf 1.56 mg, Ginko biloba extract
.3 mg, Citru bioflavonoids 7.8 mg, Seleniumcitrate 3.2 mg,
Zinc citrate 1.56 mg, Green tea extract 1.56 mg, Tumeric
powder 3.9 mg, Rose hips 7.8 mg, Lipoic acid 8 mg, Vitamin
E succinate 2 IU, Beta-carotene/carotenoids 7,900 IU, Flaxseed
.8 mg, CoQ10 1.6 mg, Ginseng 4 mg, Irish moss 50 mg, Kelp
algae 80 mg)
Description**
TPPTM Inflammatory Control is a unique
formulation of highly active proteolytic enzymes, vitamins,
minerals and herbs designed to help modulate the inflammation
process. The synergistic action of the highly absorbable
enzymes and powerful, natural ingredients facilitates the
removal of oxidized molecules and necrotic tissue, aids
in the modulation of free radicals and supports the regulation
of cytokines. This product also supports the healing and
mediating molecules of the body thus enhancing the overall
health and vitality of the body.
Studies have indicated that oral hydrolytic enzymes affect
cytokine synthesis and modulatory effects.1 For instance,
TNF-a synthesis, which is a necessary step in host defense
against tumor cells,2 was impaired when experimentally inactivated
oral proteolytic enzymes were used.3 Thus, active, gastroinlestinal
stable and functional oral enzymes that are absorbed in
the blood stream can provide therapeutic applications. In
addition, studies have shown that oral proteolytic enzymes
increased the tumoricidal and cytotocb activities of polymolphonuclear
meutrophils.4 Bromelain, a protease derived from the pineapple
plant, has been used for many years as a digestive aid,
bum debridement agent and anti-inflammatory agent. Its actions
help to prevent swelling/edema, promote smooth muscle relaxation,
inhibit platelet aggregation and enhance antibiotic absorption.
Bromelain is also used in ulcer prevention, sinusitis relief,
cancer treatment, appetite inhibition and shortening of
labor.5,6
TzymeTM Anti-Ox Blend - This comprehensive
blend of antioxidant ingredients scavenges and corrects
molecules damaged by free radicals, thus helping to prevent
a free radical domino effect within the body. The natural
minerals, bioflavonoids, herbs and vitamins in this unique
formulation are designed to help the body control inflammation
and enhance the healing process.
Rutin, a bioflavonoid, has been demonstrated
to be a potent anti-inflammatory agent in recent studies,
in part due to inhibiting phospholipase A2.7
Quercetin, a bioflavonoid, has been shown
to modify eicosanoid biosynthesis (antiprostanoid and anti-inflammatory
responses).8 It has been found to inhibit membrane lipid
peroxidation.9 Quercetin has potent anticarcinogenic, antioxidative
and anti-inflammatory properties.10
Grape Seed Extract contains concentrated
procyanidolic oligomers (PCO), which are mixtures of dimers,
trimers, and larger polymers of proanthocyanidins. The PCO's
scavenge free radicals and inhibit decarboxylase in the
inflammatory process, thereby reducing inflammation. PCO's
are among the best-studied and most effective bioflavonoids,
based in part on their powerful antioxidant activity.11
Kelp and Irish Moss are rich sources of
a wide variety of minerals, including potassium, sodium,
calcium, chlorine, copper, iron, iodine, selenium, zinc,
bromine and manganese.12 One consequence of inflammation
is a sizable loss of body nitrogen, potassium, magnesium,
phosphate, and zinc and the subsequent retention of body
salt and water.
TzymeTM Protease Blend - This proprietary
blend of enzymes consists of alkaline, neutral, and acid
protease, exo/endo peptidase, bromelain and papain. These
enzymes are active in a wide range of pH's, ensuring that
proper protein digestion will initiate in the stomach. The
addition of the endo- and exo-peptidase in this product,
which provides a wider range of specificities, ensures the
highest degree of protein hydrolysis.
Indications:
Slow Tissue Repair - Tissue repair or wound
healing is usually divided into three phases. The inflammatory
phase is characterized by platelet accumulation, coagulation
and leukocyte migration. The proliferate phase involves
re-epithelialization, angiogenesis, fibroplasia and wound
contraction. The remodeling phase takes place over a period
of months. During this stage of tissue repair, the dermis
responds to injury with the production of collagen and matrix
proteins and then returns to its pre-injury structure. Research
has shown that these processes are regulated by various
cytokines.13 Oral protease supplementation leads to the
formation of activated a2M, which significantly modulates
tissue cytokines.14
Recommended Dosages:
Take three (3) to five (5) capsules three times daily for
acute injury. Take one (1) to three (3) capsules three times
daily for a chronic inflammatory condition. If you have
difficulty swallowing capsules remove contents from capsule,
mix with a small amount of tepid water and ingest immediately.
This product should be taken on an empty stomach.
Dosage may be increased according to need and/or as indicated
by your health care professional.
References:
-
Desser L., Rehberger A., et al. 1993:
Int. J. of Cancer Res. And Treatment, 50:403.
-
Arai K., Lee F., et al., 1990: Ann.
Rev., Biochem, 59:783.
-
Desser L., Rehberger A., and Paukovits
W. 1994: Cancer biotherapy, 9:253..
-
Zavadova E., Desser L., et al., 1995:
Cancer Biotherapy, 10:147.
-
Taussig S.J., and Batkin S., et al.,
1988: J. Ethnopharmacol, 22:191.
-
Gerard G., 1972: Agressology, 13:261.
-
Lindohl M., & Tagesson C., "Flavonoids
as phospholipase A2 inhibitors: Importance of their structure
for selective inhibition of group II phospolipae A2",
Inflammation 1997; 21:347-56.
-
Formica J.V., Regelson W., "Review
of the biology of Quercetin and related bioflavonoids",
Food Chem Toxicol 1995; 33:1061-80.
-
Laughton M.J., Halliwell B., Evans
P.J., and Hoult J.R., "Antioxidant and pro-oxidant
actions of the plant phenolics quercetin, gossypol and
myricetin. Effects on lipid peroxidation, hydroxyl radical
generation and bleomycin-dependnet damage to DNA",
Biochem Pharmacol 1989; 38:2849-2865.
-
"Potential Health Effects of the
Dietary Flavonol Quercetin", Hertog M.G.L., and Hollman
P.C.H., European Journal of Clinical Nutrition 1996; 50-63-71.
-
Absorption of Orally Administered Enzymes,
M.L.G. Gardner and K.-J. Steffens, eds., Springer-Verlag,
Berlin, 1995.
-
The Encyclopedia of Medicinal Plants,
A. Chevallier, DK Publishing, New York, 1996, p. 211.
-
Moulin V., "Growth factors in
skin wound healing", Eur J. Cell Biol 1995; 68:1-7.
-
LaMarre J. Wollenberg G.K., Gonias
S.L. & Hayes M.A., "Biology of Disease: Cytokine
binding and clearance properties of proteinase-activated
a2-macroglobulins", Lab Inv 1991; 65:3-14.