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DIM (IndoleGard)® Enhanced Delivery System, Allergy Research Group
(Safe, stable and bioavailable form of I3C)
Natural Support For Healthy Estrogen Balance

Price: $39.95
Quantity: 120 capsules / 300 mg
Ingredients: BioResponse DIMTM, Cellulose, food grade starch, vitamin E succinate, phosphatidylcholine, silica, and carbowax.

Quantity:

Description**
How Your Patients May Benefit from DIM, dietary supplement:

Maintains healthy reproductive tissue, e.g. breast and cervix and prostate
Promotes healthier estrogen metabolism and balance
Helps promote the conversion of estrogen to its beneficial, protective 2 hydroxyestrone metabolites and reduces production of genotoxic 16 a-hydroxyestrone
Stimulates detoxification enzyme systems
Helps to promote a healthy mood and sense of well-being in perimenopausal years
May be beneficial for women with estrogen-dominant health conditions and those on hormone replacement therapy (HRT)

DIM (Diindolylmethane) has been shown to help regulate and promote a more efficient metabolism of estrogen, and an optimal ratio of estrogen metabolites.

DIM® Enhanced Delivery System BioResponse DIMTM, a unique formulation containing pure Diindolylmethane, an indole. Indoles are plant compounds with health promoting properties, and are found in cruciferous vegetables such as broccoli, cabbage, cauliflower and Brussels sprouts.

DIM® Enhanced Delivery System is a stable, bioavailable form of DIM, made possible through a proprietary delivery system. The formula is co-solubilized with phosphatidylcholine, and microencapsulated in starch particles.

Research over the past thirty years has determined that disrupted estrogen metabolism is closely linked to several health risks in men and women, particularly those involving the breast, uterus, prostate and other reproductive tissue. Genetics, excess weight, poor diet and other lifestyle factors may result in an imbalance of estrogen metabolites. Xenoestrogenic compounds of the modern world, such as organochlorine pesticides, can significantly disrupt healthy estrogen metabolism.

These estrogen disruptors alter estradiol hydroxylation metabolism producing a higher ratio of the genotoxic 16 alpha-hydroxyestrone (16 a-OHE1) to the safer and weaker estrogenic 2-hydroxyestrone (2-OHE1). The genotoxic 16 a-OHE1 stimulates cellular proliferation, increases oncogene expression, and inhibits apoptosis. It is clear that modulating these aspects of estrogen metabolism, particularly the production of 16 a-OHE1, can contribute to healthy aging.

The phytochemicals in cruciferous vegetables have been shown to beneficially affect the body's hormonal and detoxification systems. Epidemiological studies have supported the health benefits of consuming these vegetables.

DIM is a major active acid-catalyzed derivative of one of the phytochemicals in cruciferous vegetables, indole-3-carbinol (I3C). DIM is thought to be responsible for the health effects of dietary I3C. Research using human breast cells (MCF-7) has shown that DIM not only inhibits cell growth, but also induces apoptosis. These results involve DIM binding to the aryl hydrocarbon receptor (AhR) resulting in rapid formation of the nuclear AhR complex and consequent induction of gene expression and synthesis of cytochrome P450 detoxification enzyme (CyP450A1). DIM consequently produces increased levels of the protective hydroxylated estrogen 2-OHE1.

The mechanisms for DIM's health benefits primarily involve the induction of mixed function oxidases and phase II detoxification enzyme systems by the binding and activation of the arylhydrocarbon receptor. Some have suggested that DIM may also positively affect cellular signaling pathways, and thus regulate tumor promotion and progression. It is becoming increasingly apparent that dietary supplements like DIM may provide an important mechanism for maintaining successful aging despite the increasing levels of xenoestrogenic compounds in our modern world.

Caution: Do not use this product if you are pregnant or lactating, or using birth control pills.

Note: Harmless changes in urine color may occur. Increased water consumption reverses this side effect.

References

Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9.
Ben-Jonathan N, Cooper RL, Foster P, et al. An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults. Environ Health Perspect 1999;107 Suppl 4:605-11.
Bradlow HL, Davis D, Sepkovic DW, et al. Role of the estrogen receptor in the action of organochlorine pesticides on estrogen metabolism in human breast cancer cell lines. Sci Total Environ 1997;208:9-14.
Bradlow HL, Sepkovic DW, Telang NT, et al. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. Ann N Y Acad Sci 1999;889:204-13.
Chang YC, Riby J, Chang GH, et al. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'- diindolylmethane, a major in vivo product of dietary indole-3-carbinol. Biochem Pharmacol 1999;58:825-34.
Chen I, Safe S, Bjeldanes L. Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells. Biochem Pharmacol 1996;51:1069-76.
Davis DL, Telang NT, Osborne MP, et al. Medical hypothesis: bifunctional genetic-hormonal pathways to breast cancer. Environ Health Perspect 1997;105 Suppl 3:571-6.
Ge X, Fares FA, Yannai S. Induction of apoptosis in MCF-7 cells by indol-3-carbinol is independent of p53 and bax. Anticancer Res 1999;19:3199-203.
Lake BG, Tredger JM, Renwick AB, et al. 3,3'-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11.
Michnovicz JJ, Adlercreutz H, Bradlow HL. Changes in levels of urinary estrogen metabolites after oral indole-3- carbinol treatment in humans. J Natl Cancer Inst 1997;89:718-23.
Riby JE, Chang GH, Firestone GL, et al. Ligand-independent activation of estrogen receptor function by 3, 3'- diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77.
Sanderson JT, Slobbe L, Lansbergen GW, et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicol Sci 2001;61:40-8.
Shertzer HG, Senft AP. The micronutrient indole-3-carbinol: implications for disease and chemoprevention. Drug Metabol Drug Interact 2000;17:159-88.
Wattenberg LW, Loub WD. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res 1978;38:1410-3.

** Disclaimer: All information presented by Natural Healing House is for educational purposes only. The articles are not intended to substitute for a consultation with your physician. In case of medical questions or uncertainties, the reader is encouraged to seek the advice of his/her own physician or health care practitioner. The products listed have no